In this keynote lecture, Mel Chen traces colonial administrations of race and disability to show their entanglements in creating the intoxicated subjects of different moments in time. Chen examines the conceptual territories of toxicity and intoxication, drawing on nineteenth-century archival histories of the interanimation of race and disability, in particular with regards to early research on Down Syndrome and the usage of opium. Throughout history and up until the present moment’s ‘environmentalization’, constructs based upon race and disability have been used to collapse people and their environments, thus evoking the term ‘mindbody’, which—like Haraway’s term ‘natureculture’—seeks to think inseparable two things often times stylized as opposites. Chen’s work highlights the ways in which environmental pollutants and toxic substances create visions and intersections, which they implement and put to the fore in terms of agitation, blurriness, and intoxication as method. Through this research, Chen proposes a productive moment of rethinking the boundaries of self and other. How do instances of intoxication shift the modi of making sense?